Novel Symmetrical Cage Compounds as Inhibitors of the Symmetrical MRP4-Efflux Pump for Anticancer Therapy
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Symmetrical bis(heteroarylmethoxyphenyl)alkylcarboxylic acids as inhibitors of leukotriene biosynthesis.
Symmetrical bis(quinolylmethoxyphenyl)alkylcarboxylic acids were investigated as inhibitors of leukotriene biosynthesis and 4, 4-bis(4-(2-quinolylmethoxy)phenyl)pentanoic acid sodium salt (47.Na) met our design parameters for a drug candidate (ABT-080). This compound was readily synthesized in three steps from commercially available diphenolic acid. Against intact human neutrophils, 47.Na inhib...
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چکیده ندارد.
15 صفحه اولSynthesis of symmetrical and non-symmetrical diimines from dimedone.
Symmetrical and non-symmetrical diimines derived from dimedone were synthesized by the reaction of their corresponding enaminothiones with primary amines. The synthesized compounds were characterized using micro analytical data and NMR spectroscopy. Theoretical calculations by B3LYP/6-31G(d,p) level of theory show that the enolic form is the most stable within the possible tautomeric forms of t...
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THE YOUNG INFANT with cyanotic congenital cardiac disease presents an acute and difficult diagnostic problem. The anomalies responsible for eyanosis in some such infants are now curable surgically while, on the other hand, there remains a group of eyanotic newborn infants in whom the congenital cardiac anomalies are so complex that no surgical procedures for their correction have yet been devis...
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Symmetrical gangrene is a condition in which gangrene occurs in all four limbs, the nose and ears at the same time. This is a rare condition and only very few cases have been recorded. A number of conditions can cause symmetrical gangrene. These areas, i.e. the limbs, the ears and the nose, represent the outposts of the cardiovascular system. When the body needs to conserve, it conserves at the...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22105098